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. Author manuscript; available in PMC: 2021 Oct 23.
Published in final edited form as: Dev Dyn. 2014 Sep 22;244(1):56–68. doi: 10.1002/dvdy.24178

Fig. 6. Neural crest-derived cell migration is correlated with vasculogenesis, not angiogenesis.

Fig. 6.

A: P75+ neural crest-derived cells (NCDCs, red) arrive in the gut shortly following neovascularization to colonize the first half of the small intestine by E10.5. B-C: As the colonic capillary plexus is established at E11.5-E12.5, NCDCs continue their migration to reach the cecum by E11.5 and the distal portion of the colon at E12.5. A’-C’: The migration front of NCDCs (red, arrows) never reaches a region without an established capillary plexus (blue, open arrowheads). Further, NCDCs are found closely adjacent to capillaries. However, despite the apparently close relationship between NCDCs and endothelial cells, higher magnification (C’) reveals that NCDCs (arrows) migrate outside of the submucosal vascular layer and do not appear to directly contact endothelial cells (open arrowheads). Scale bars = 100 μm except where indicated.