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. 2021 Oct 14;22(20):11101. doi: 10.3390/ijms222011101

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Telomere maintenance mechanism in metastasis cancer. (A) Heat map of four types of telomere maintenance mechanisms in metastasis cancer. TEL+ALT: telomerase and alternative lengthening of telomere, TEL: telomerase, NDTMM: non–defined TMM (no/low activity of telomere maintenance mechanism), ALT: alternative lengthening of telomere. (B) Kaplan–Meier plots showing the overall survival rates for the four types of TMM in metastasis cancers. (C) Enriched biological process in ALT samples. (D) Enriched biological process in NDTMM samples. (E) Transcriptional factors and their target genes for ALT in metastasis cancer. (F) Heat map of correlation between S phase and significant transcriptional factors (orange: positive, blue: negative). (G) Box plot of E2F1 expression in the four TMM types. (H) Frequency of TMM for each tumor grade.