Figure 8.

Comparison of the analgesic effects of intraperitoneal (i.p.) administration of different doses (1, 5, or 10 mg/kg) of (±)-NBI 74330 (A,B) and NVP CXCR2 20 (C,D) on the 7th day after chronic constriction injury in mice. The effects of single i.p. NBI and NVP injections on mechanical (A,C) and thermal (B,D) hypersensitivity were measured. The results are presented as a percentage of the maximal possible effect (% MPE = (post-drug response − basal response)/(cutoff value − basal response) × 100%) of drug action (A–D), and the area under the curve (AUC) for each test was calculated (E,F). Data are presented as the means ± SEM (4–6 mice per group). The results were evaluated using one-way ANOVA followed by Bonferroni’s test for comparisons of selected pairs measured separately at each time point. Additionally, the results were evaluated using two-way ANOVA to determine the time × drug interaction. # p < 0.05 and ### p < 0.001 for the comparison of vehicle-treated animals with all groups at the indicated time points. & p < 0.05, && p < 0.01, and &&& p < 0.001 for the comparison of different doses of NVP, and the same doses of NVP with NBI. Abbreviations: vehicle, V; (±)-NBI 74330, NBI; NVP CXCR2 20, NVP.