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. 2021 Jul 3;24(10):759–775. doi: 10.1093/ijnp/pyab037

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© The Author(s) 2021. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Methods to investigate psychiatric disorders. I: Animal models; (A) psychometric scores, (B) neuroimaging, (C) post-mortem tissue, (D) genetics; (1) somatic cells (including PBMCs, lymphoblastoid cell lines, and fibroblasts) used to generate induced neurons through transdifferentiation (1B) or induced pluripotent stem cells (1A). The iPSCs can then be used to generate different neuronal subtypes types or organoids. (2) Acquisition of olfactory neuroepithelium to obtain olfactory neurons (2B) and olfactory stem cells (2A). These can be used to create neurospheres and different subtypes, including neurons, astrocytes, and oligodendrocytes.