Table 1.
miRs’ expression in different blood compartments of patients with MDD compared to healthy controls.
| Study (Year, Reference No) | Patients | Controls | Blood Compartment | Upregulated miRs | Downregulated miRs | Unchanged miRs | Total |
|---|---|---|---|---|---|---|---|
| Belzeaux et al., 2012 [32] | 16 | 13 | PBMCs | miR-107 miR-133a miR-148a miR-425-3p miR-494 miR-579 miR-652 miR-941 miR-589 |
miR-200c miR-381 miR-571 miR-636 miR-1243 |
- | 9 upregulated, 5 downregulated |
| Li YJ et al., 2013 [33] | 40 | 40 | Serum | miR-132 miR-182 |
- | - | 2 upregulated |
| Fan et al., 2014 [34] | 81 | 46 | PBMCs | miR-26b miR-1972 miR-4485 miR-4498 miR-4743 |
- | - | 5 upregulated |
| Li J et al., 2015 [35] | 18 | 18 | Whole blood | miR-644 miR-450b miR-328 miR-182 |
miR-335 miR-583 miR-708a miR-650 miR-654a |
miR-541 miR-663 miR-578 |
4 upregulated, 5 downregulated, 3 unchanged |
| Camkurt et al., 2015 [36] | 50 | 41 | Plasma | miR-451a miR-17-5p miR-223-3p |
miR-320a | miR-25-3p miR-126-3p miR-16-5p miR-93-5p |
3 upregulated, 1 downregulated, 4 unchanged |
| Wan et al., 2015 [37] | 38 | 27 | Serum | let-7d-3p miR-34a-5p miR-221-3p miR-125a-5p miR-30a-5p miR-29b-3p miR-10a-5p miR-375 miR-155–5p miR-33a-5p miR-139–5p |
miR-451a miR-15b-5p miR-106-5p miR-590-5p miR-185-5p |
- | 11 upregulated, 5 downregulated |
| Wang X et al., 2015 [38] | 169 | 52 | Plasma | - | miR-144-5p | - | 1 downregulated |
| Mafioletti et al., 2016 [39] | 20 | 20 | Peripheral venous blood | hsa-miR-199a-5p hsa-miR-24-3p hsa-miR-425-3p hsa-miR-29c-5p hsa-miR-330-3p hsamiR-345-5p |
hsa-let-7a-5p hsa-let-7d-5p has-let-7f-5p has-miR-1915-3p |
hsa-miR-720 hsa-miR-140-3p hsa-miR-1973 hsa-miR-30d-5p hsa-miR-3158-3p hsa-miR-330-5p hsa-miR-378a-5p hsa-miR-1915-5p hsa-miR-1972 hsa-miR-21-3p hsa-miR-4521 hsa-miR-4793-3p hsa-miR-4440 |
6 upregulated, 4 downregulated, 13 unchanged |
| Sun et al., 2016 [40] | 32 | 32 | Peripheral blood leukocytes | miR-34b-5p miR-34c-5p |
- | miR-369–3p miR-381 miR-107 |
2 upregulated, 3 unchanged |
| He et al., 2016 [41] | 32 | 30 | PBMCs | miR-124 | - | - | 1 upregulated |
| Roy et al., 2017 [42] | 18 | 17 | Serum | miR-124-3p | - | - | 1 upregulated |
| Kuang et al., 2018 [43] | 84 | 78 | Serum | miR-34a-5p miR-221-3p |
miR-451a | - | 2 upregulated, 1 downregulated |
| Fang Y et al., 2018 [44] | 45 | 32 | Plasma | miR-124 miR-132 |
- | - | 2 upregulated |
| Gheysarzadeh et al., 2018 [45] | 39 | 36 | Serum | - | miR-16 miR-135a miR-1202 |
- | 3 downregulated |
| Hung et al., 2019 [46] | 84 | 43 | PBMCs | miR-21-5p miR-145 miR-223 |
miR-146a miR-155 let-7e |
- | 3 upregulated, 3 downregulated |