Table 1.

Structural and functional predictions.

HAs	Predictions
	Structural	Functional
	TM-Score	SIA-Binding C-Score
cHA-C	0.831	0.77
cHA-E	0.836	0.7
A/Michigan/45/2015 (H1N1) pdm09-like virus (CVV-M)	1	1

Note: Here is the figurative representation of the predictions made on the structures and functions of the cHAs to a typical HA molecule. Whilst TM scores provide inference into structural similarity of a query protein sequence to a hit template and ranges in likelihood from 0 to 1, the C-score, also ranging from 0 to 1 (or 0% to 100%), infers on functional similarity of a query protein sequence. CVV-M was assumed to be 1 for both the TM-score and C-score, whereas cHA-C and cHA-E were each about 80% structurally similar and had 70% potential to be similar in function as typical HAs.