Table 4.
Baseline/sero-converted blood assessment to influenza A (H1N1) pdm09.
| Serum | Baseline | 3D | ||||||
|---|---|---|---|---|---|---|---|---|
| Virus | cHA-C | cHA-E | CVV-M | U | cHA-C | cHA-E | CVV-M | U |
| X-275 | <20 | <20 | <20 | <20 | 320 | 1280 | 640 | <20 |
| A/England/195/2009 (H1N1) pdm09 | <20 | <20 | <20 | <20 | 320 | 320 | 320 | <20 |
| PNJ | <20 | <20 | <20 | <20 | 160 | 160 | 160 | <20 |
Note: Here, seroconverted serum (3rd week serum drawn, 3D) is indicated to have generated significantly elevated haemagglutination inhibition titres compared with the baseline blood drawn. With the 3D, the H1-based cHAs (cHA-C and cHA-E) induced anti-cHAs antibodies that both reacted with H1-bearing viruses (the X-275 and A/England/195/2009) and an H5N2 virus (PNJ). A similar situation was observed for the control, CVV-M. The naïve control, U, remained constantly non-converted.