Table 6.
Binding effectiveness of top-ranking environmental toxicants in binding pockets of receptors.
| Environmental Toxicants | Androgen Receptor | Estrogen Receptor-α | Estrogen Receptor-β | ||||||
|---|---|---|---|---|---|---|---|---|---|
| LE a | BEI | LipE | LE a | BEI | LipE | LE a | BEI | LipE | |
| Bisphenol A | 0.49 | 40 | 6 | 0.45 | 38 | 5 | 0.46 | 39 | 5 |
| Dichlorodiphenyltrichloroethane | 0.42 | 25 | 2 | - | - | - | - | - | - |
| Diethylstilbestrol | 0.43 | 35 | 4 | 0.43 | 34 | 4 | 0.43 | 35 | 4 |
| O-phenylphenol | 0.60 | 51 | 6 | - | - | - | - | - | - |
| Perfluorooctanoic acid | 0.36 | 23 | 1 | - | - | - | - | - | - |
| Permethrin | - | - | - | - | - | - | 0.30 | 23 | 3 |
LE: ligand efficiency, BEI: binding efficiency index, LipE: lipophilic efficiency, a: kcal/mol.