Table 2.
Maternal body weight during gestation and lactation and plasma profile at weaning.
| CH-CT (n = 8) |
CH-MT (n = 5) |
HF-CT (n = 8) |
HF-MT (n = 6) |
|
|---|---|---|---|---|
| Body weight (g) | ||||
| Before pregnancy | 209.1 ± 5.1 | 209.7 ± 5.1 | 211.4 ± 4.6 | 207.5 ± 6.5 |
| GD10 | 265.4 ± 7.9 | 201.4 ± 16.9 # | 265.9 ± 6.1 | 234.5 ± 6.4 # |
| GD20 | 342.5 ± 15.8 | 298.0 ± 14.4 # | 337.0 ± 8.7 | 284.7 ± 6.7 # |
| PND21 | 296.9 ± 6.4 | 293.8 ± 8.9 | 270.4 ± 6.4 § | 262.5 ± 6.7 § |
| Plasma profile | ||||
| Glucose (mmol L−1) | 8.6 ± 0.3 | 8.7 ± 0.1 | 8.0 ± 0.2 | 8.7 ± 0.2 |
| Insulin (mU L−1) | 35.9 ± 1.3 | 26.7 ± 1.7 # | 43.7 ± 2.4 § | 30.8 ± 2.7 #,§ |
| TG (mmol L−1) | 5.3 ± 0.3 | 4.5 ± 0.5 # | 6.4 ± 0.6 | 4.3 ± 0.5 # |
| Cho (nmol mL−1) | 2.4 ± 0.2 | 2.1 ± 0.1 # | 2.8 ± 0.2 | 2.1 ± 0.2 # |
| Leptin (ng mL−1) | 5.2 ± 0.7 | 5.3 ± 0.5 | 5.1 ± 0.6 | 5.2 ± 0.6 |
Values are expressed as mean ± standard error of mean (SEM). n, number of dams per group; GD, gestation day; PND, postnatal day; TG, triglyceride; Cho, Cholesterol. Data were analyzed by a two-way ANOVA, # main effect of maternal metformin, p < 0.05 versus control, § main effect of maternal HF diet, p < 0.05 versus maternal CHOW diet.