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. 2021 Sep 29;11(10):2569. doi: 10.3390/nano11102569

Table 5.

Application of nHA for delivery of other drugs or bioactive molecules.

Author (Year) Interventions Dosage Delivery Approach Significant Findings
Hu et al. (2021) [21]
  • (1)

    Gel (blank control)

  • (2)

    Gel + HA

  • (3)

    Gel + HA-D

  • (4)

    Gel + HA-D + M

  • (5)

    Gel + HA-D + Cal

  • (6)

    Gel + HA-D + M + Cal
  • (1)

    HA-D + M: HA-D + 10 mg PCL-PEG-NH2 copolymers micelle (M)

  • (2)

    HA-D + Cal: HA-D + 0.3 mg/mL Cal

  • (3)

    HA-D + M + Cal: HA-D + M + 0.3 mg/mL Cal

 Implantable hydrogel system Hydrogel systems containing HA showed significantly higher new bone formation compared to blank control, especially in the presence of HA-D, M, and Cal
Jia et al. (2021) [22]
  • (1)

    Blank control

  • (2)

    nHA

  • (3)

    nHA-MS

  • (4)

    Dex + nHA-MS
  • (1)

    nHA-MS: 0.2 g

  • (2)

    Dex + nHA-MS: 20 mL Dex solution of 0.1 mg/mL + 0.2 g nHA-MS

 Implantable scaffold Defects implanted with nHA scaffolds have higher new bone formation compared to blank control, which barely showed any bone regeneration
Luo et al. (2019) [31]
  • (1)

    Blank control

  • (2)

    OSA-CS-Borax

  • (3)

    OSA-CS-PHA

  • (4)

    OSA-CS-PHA-DDP
  • (1)

    OSA–CS–Borax: OSA + CS hydrogel + 0.02 g of Borax

  • (2)

    OSA–CS–PHA: OSA + CS + 0.3 g of PHA

  • (3)

    OSA–CS–PHA–DDP: OSA + CS + 0.3 g of PHA loaded with DDP

 Implantable hydrogel system The defect implanted with OSA–CS–PHA hydrogel showed large areas of new bone formation compared to the blank control and OSA–CS–Borax hydrogel implant
Tavakoli-Darestani et al. (2014) [27]
  • (1)

    Blank control

  • (2)

    HA

  • (3)

    Dex/HA
  • (1)

    Dex/HA: HA particles + 0.01 g/mL Dex

 Implantable bioceramic Defects implanted with HA bioceramics (with and without Dex) showed bone regeneration compared to blank control, which did not show any bone regeneration

Abbreviations: HA, nHA—nano-hydroxyapatite; HA-D—polydopamine coating nano-hydroxyapatite; PCL-PEG-NH2—amino-terminated poly(ethylene glycol)-block-poly(epsilon-caprolactone) copolymers; M—PCL-PEG-NH2 copolymers micelle; Cal—calcitriol; nHA-MS—nHA surface coated with mesoporous silica thin film; Dex—dexamethasone; OSA-CS—sodium alginate–chitosan; PHA—polydopamine-decorated nHA; DDP—cisplatin; Dex/HA—dexamethasone-loaded hydroxyapatite particles.