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Percentage distribution of CLO in the films F1–F3.
| Formulation | CLO Content (%) | |
|---|---|---|
| PC Layer | CS Layer | |
| F1 | 50.0 | 50.0 |
| F2 1 | 33.3 | 66.7 |
| F3 1 | 0.0 | 100.0 |
PC—pectin, CS—chitosan, CLO—clotrimazole, 1 Due to the limited solubility of CS, CS layer was proposed as a gradually eroded reservoir with higher drug content.
