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. 2021 Sep 23;13(10):1913. doi: 10.3390/v13101913

Figure 3.

Figure 3

Comparison of the CATC location and occupancy on the capsid among the representatives of the three human herpesvirus subfamilies. In both alpha (HSV-1/2) and gammaherpesviruses (EBV/KSHV), the CATC (purple raindrops) is composed of three proteins (HSV1/2: UL17, UL25, and UL36; EBV: CVC1, CVC2, and LTP; KSHV: ORF32, ORF19, and ORF64) and is located at capsid pentonal vertices. CATC on HSV1/2 capsids is present at a full occupancy whereas CATC on gammaherpesvirus capsids is present at a lower occupancy. Unusually, HCMV has two types of CATCs. The first CATC type (purple raindrops) is the conserved complex of UL93, UL77, and UL48 (homologs of UL17, UL25, and UL36) present at the lowest occupancy and positioned slightly below pentons. The other CATC type (red triangles) is betaherpesvirus-specific and covers the entire capsid like a net. In all three subfamilies, the portals are fully occupied by the CATC. Insets show CATC location relative to the MCP hexons, MCP pentons, and triplexes. For clarity, the SCP is not shown. The HSV-1/2 inset shows the 3D structure of this region of the HSV-1 capsid (UL25 globular domains not shown; PDB: 6CGR), generated using Chimera [79]. This figure was created with BioRender.com, accessed on 17 September 2021.