. 2021 Oct 12;26(20):6151. doi: 10.3390/molecules26206151

Table 4.

Toxicity properties of candidates.

Comp.	FDA Rodent Carcinogenicity (Mouse-Female)	Carcinogenic Potency TD₅₀ (Mouse) mg/kg Body Weight/Day	Rat Maximum Tolerated Dose (Feed) ^a	Rat Oral LD₅₀ ^a	Rat Chronic LOAEL ^a	Ocular Irritancy	Skin Irritancy
48	Non-Carcinogen	9.295	0.191	0.778	0.018	Severe	Mild
182	Non-Carcinogen	4.245	0.175	1.119	0.010	Moderate	Mild
220	Single-Carcinogen	67.851	0.095	6.173	0.009	Moderate	Mild
221	Single-Carcinogen	55.437	0.094	4.343	0.006	Moderate	Mild
284	Multi-Carcinogen	6.402	0.155	1.213	0.004	Moderate	Mild
Ribavirin	Non-Carcinogen	13.111	0.154	0.750	0.013	Mild	Mild

^a Unit = g/kg body weight.