Skip to main content
. 2021 Oct 7;13(10):2015. doi: 10.3390/v13102015

Figure 2.

Figure 2

Diagram of the viral factors associated at a viral replication fork during HSV-1 DNA replication. Following the binding of the origin binding protein UL9 (not shown), DNA is unwound and RNA primers are synthesized by the helicase–primase complex (UL5, UL8, and UL52), shown in purple. The single-stranded DNA binding protein ICP8 coats single-stranded DNA (green). The viral polymerase UL30 (blue) and the processivity factor UL42 (beige) carry out leading (top) and lagging (bottom) strand synthesis. The RNA primers are shown in light blue. Created with BioRender.com, accessed on 28 September 2021. Adapted from Dembowski, Dremel, and DeLuca, PLoS Pathogens, 2017 [15].