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Hypothetical model of the mechanism of sexual functioning improvement by amantadine. The drug acts as a prodopaminergic modulator of the reward system (ventral tegmental area and nucleus accumbens), increasing the dopaminergic activation suppressed by antipsychotic therapy. DDC—L-DOPA decarboxylase; MAO-B—monoaminoxidase B; DAT—dopamine transporter; AC—adenyl cyclase; PKA—protein kinase A.
