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. 2021 Oct 11;10(20):4649. doi: 10.3390/jcm10204649

Table 2.

Ongoing clinical trials with immunotherapy in GC.

Rank NCT Number Title Conditions Interventions Phases Completion Date
1 NCT04889768 HIPEC Combined with Camrelizumab, Paclitaxel and S-1 for Conversion Therapy in Patients With Advanced Gastric Cancer With Peritoneal Metastasis Gastric Cancer, HIPEC, Anti-PD-1 Antibody Camrelizumab (SHR-1210), Chemotherapy and Surgery Drug: HIPEC, anti-PD-1 antibody Camrelizumab (SHR-1210), Chemotherapy and Surgery Not Applicable July 31, 2025
2 NCT04694183 The Conversion Therapy of Chemotherapy Plus Camrelizumab in Metastatic Gastric Cancer Gastric Cancer Drug: Paclitaxel + S-1 + anti-PD-1 antibody (Peritoneal metastasis) |Drug: SOX regimen + anti-PD-1 antibody (Liver metastasis, para-aortic lymph node metastasis) Phase 2 November 17, 2022
3 NCT03682744 CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC) Peritoneal Carcinomatosis|Peritoneal Metastases|Colorectal Cancer|Gastric Cancer|Breast Cancer|Pancreas Cancer|Carcinoembryonic Antigen Biological: anti-CEA CAR-T cells Phase 1 March 2021
4 NCT03252938 Feasibility and Safety of IMP321 for Advanced Stage Solid Tumors Solid Tumors|Peritoneal Carcinomatosis Drug: IMP321|Drug: Avelumab Phase 1 June 30, 2024
5 NCT01784900 Treatment of Gastric Peritoneal Carcinomatosis by Association of Complete Surgical Resection of the Lesions and Intraperitoneal Immunotherapy Using Catumaxomab Patients With Gastric Peritoneal Carcinomatosis Drug: Catumaxomab 100 µg|Drug: Catumaxomab 140 µg Phase 2 January 2016