Figure 2.

KLF2-mediated regulation of the differentiation and migration of naïve T cells, TFH cells and naïve B cells. In naïve T cells, KLF2 induces the upregulation of S1PR1, L-Selectin and Itgβ7. In TFH cells, KLF2 is downregulated to low levels (by ICOS/ICOSL signals). Downregulation of KLF2 in TFH cells results in upregulation of CXCR5 and downregulation of Blimp1, CCR7, PSGL-1, S1PR1 and L-Selectin. In naïve FO B cells, KLF2 regulates L-Selectin and Itgβ7 expression which might affect B cell migration to lymph nodes, bone marrow and mucosal tissues. Downregulation is indicated by red arrows; upregulation is indicated by green arrows.