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Schematic diagram of the model (top) for the L-type calcium channel (DHPR channel) from [29]. C1 and C6 are closed states with C6 the resting state. O2 and O3 are the open states that conduct Ca2+ ions with equal conductance. C4 is Ca2+-dependent inactivated state. C5 is the voltage-dependent inactivated state. The fraction of LCC channels in different states during the voltage-clamp of Vstim = +10 mV for 200 ms (bottom).
