Figure A5.

Pacing at 8 Hz pacing produces alternans with diastolic [Na⁺]I = 20 mM. To emulate the excitation-contraction of the cell, a stimulus current I_stim = −6.5189 µA/cm² was given during 5.0 ms second [40]. (A) [Ca²⁺]_myo; (B) Membrane potential (V_m); (C) Network SR Ca²⁺ concentration ([Ca²⁺]_nsr); (D) RyR2 open probability (P_O,RyR); (E) L-type Ca²⁺ channel open probability (P_O,LCC); (F)subspace free Ca²⁺ concentration ([Ca²⁺]_ds); (G) L-type Ca²⁺ current (I_LCC); (H) NCX current (I_ncx); (I) PMCA current (I_PMCA); (J) Ca²⁺ current (I_Na); (K) Na/K exchanger current; (L) K1 current; (M) slow component of transient-outward K⁺ current; (N) fast-component of transient-outward K⁺ current; (O) Na⁺ current; (P) Na⁺-K⁺ ATPase current; (Q) Background Na⁺ current.