Table A1.

Parameters for L-type Ca²⁺ channel model.

$P_{o2}=\frac{-1}{1+e^{\frac{v-v_{\frac{1}{2}}}{S}}}+1$

$V_{\frac{1}{2}}=-40.344+13.31\times e^{\left(-\frac{{\left[Ca\right]}_o}{53.0}\right)}+31.65\times e^{\left(-\frac{{\left[Ca\right]}_o}{\mathrm{11,305}}\right)}+3$

$S=(0.632+0.368\times e^{(\frac{-{\left[Ca\right]}_0}{{10}^3}-0.1)/0.784)})\times (-\frac{3.792}{1+e^{(\frac{{\left[Ca\right]}_0}{{10}^3}-0.0469)/0.011)}+6.39})$

$att=130+\frac{-129}{1+e^{\frac{V_m-60}{8}}}+\frac{0.76}{1+e^{\frac{V_m-5}{3.14}}}$

${\tau }_{P_{02}}=0.00025+0.00305\times e^{-0.0045{\left(V_m+7\right)}^2}+0.00105\times e^{-0.002{\left(V_m-18\right)}^2}$

$inc{h}_{Ca}=0.89+\frac{-0.888}{1+e^{\frac{V_m-43.066}{2.289}}}\times \left(1.004+\frac{-1.199}{1+e^{\frac{\frac{{\left[Ca\right]}_o}{{10}^3}-0.259}{0.164}}}\right)$

$k_{1,5}=\frac{k_{5,1}{k}_{1,2}{k}_{2,5}}{k_{5,2}{k}_{2,1}}$

$k_{5,4}=\frac{k_{4,5}{k}_{5,2}{k}_{2,4}}{k_{4,2}{k}_{2,5}}$

$d_{dhpr}=d_{dhpr,\left({\left[Ca\right]}_0=1.8\mathrm{mM}\right)}\left(1+\frac{-1}{1+e^{\frac{\frac{{\left[Ca\right]}_o}{{10}^3}-0.08}{0.0159}}}\right)$

$k_{1,2}=0.115\times \frac{P_{O2}}{{\tau }_{O2}}$

$k_{2,1}=0.115\times \frac{1-0.155\times P_{O2}}{{\tau }_{O2}}\times att$

$k_{2,3}=0.7\times (987.3+\frac{-903.53}{1+e^{\frac{V_m-51.23}{6.785}}}$)

$k_{3,2}=500$

$k_{2,5}=0.5\times (32+\frac{-18.46}{1+e^{\frac{V_m-30}{5.746}}})\times (1-in{h}_{Ca})$

$k_{5,2}=1.0\times \left(32+\frac{-5.03}{1+e^{(V_m-30)/0.787}}\right)+\left(0.95+\frac{-0.93}{1+e^{\frac{V_m+40}{0.787}}}\right)$

$k_{2,4}=8\times \left[CaM\right]$

$k_{4,2}=1$

$k_{5,1}=6.9$

$k_{4,5}=600$

$k_{3,2}=500$

$k_{6,1}=1\times (0.0022+\frac{2998.978}{1+e^{-\left(Vm+45\right)\times 0.71428}})$

$k_{1,6}=1\times (3000+\frac{2998.978}{1+e^{-\left(Vm+45\right)\times 0.6667}})$