. 2021 Oct 7;10(10):2124. doi: 10.3390/plants10102124

Table 1.

Effect of P. granatum extracts on the HIV-1 RT-associated RNase H function and Integrase activity in the presence of LEDGF.

Extracts/Pure Compounds	HIV-1 RT-Associated RNase H IC₅₀ (µg/mL) ^a	HIV-1 Integrase LEDGF-Dependent IC₅₀ (µg/mL) ^b
Punica granatum leaves extract (PGL)	0.61 ± 0.02	0.12 ± 0.065
Punica granatum bark extract (PGB)	0.22 ± 0.04	0.18 ± 0.02
Punica granatum peel extract (PGP)	0.85 ± 0,01	0.5 ± 0.035
RDS1759	10.7 ± 0.9^c	-
Raltegravir	-	0.058 ± 0.01 ^c

^a Extract concentration required to reduce the HIV-1 RT-associated RNase H activity by 50%. ^b Extract concentration required to inhibit the HIV-1 IN catalytic activity by 50% in the presence of LEDGF. ^c Compound concentration expressed in µM.