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. 2021 Oct 13;22(20):11020. doi: 10.3390/ijms222011020

Figure 7.

Figure 7

BIRC2 expression in α7-HPV-related cervical SCC (including mixed infections). (A) Immunohistochemical testing was conducted to analyze BIRC2 protein expression in formalin-fixed paraffin-embedded samples of biopsy tissue from patients with cervical SCC (n = 373) and adjacent normal tissues (n = 168). (B) Histoscores of cervical SCC were divided into recurrent (n = 124) and nonrecurrent tumors of cervical SCC (n = 249). (C) Kaplan–Meier survival curves indicate that for patients with α7-HPV-related cervical SCC in the pooled cohort (1993–2014), having a BIRC2 histoscore of ≥175 was associated with worse CSS (p < 0.001) and (D) PFS (p = 0.008). (E) Kaplan–Meier survival curves indicate that for patients with α7-HPV-related cervical SCC (including mixed infections) in the pooled cohort (1993–2014), having a BIRC2 histoscore of ≥175 was associated with significantly worse CSS (p = 0.008) and (F) PFS (p = 0.005).