Table 1.
Characteristics of included studies.
| First Author, Year | Country | Study Design | Years | Target Condition a | Participants (n) |
|---|---|---|---|---|---|
| Ahn, 2020 [10] | Republic of Korea | RCS | 2000–2016 | NAFLD | 56 |
| Amaddeo, 2021 [11] | France | RCS | 2019–2020 | NASH | 119 |
| Bengtsson, 2019 [12] | Sweden | RCS | 2004–2017 | NAFLD | 225 |
| Benhammou, 2020 [13] | USA | RCS | 2000–2016 | NAFLD | 125 |
| Best, 2020 [14] b | Germany | RCS | 2001–2016 | NASH | 125 |
| Billeter, 2020 [15] | Germany | PCS | 2001–2017 | NASH | 62 |
| Canbay, 2020 [16] | Germany | RCS | 2011–2016 | NAFLD | 363 |
| Cotrim, 2016 [17] | Brazil | RCS | - | NAFLD | 52 |
| Debes, 2017 [18] | Argentina, Brazil, Colombia, Ecuador, Peru, Uruguay | RCS | 2005–2015 | NAFLD | 111 |
| Dyson, 2014 [19] | United Kingdom | PCS | 2000–2010 | NAFLD | 136 |
| Gawrieh, 2019 [20] | USA | RCS | 2000–2014 | NAFLD | 767 |
| Hester, 2019 [21] | USA | RCS | 2008–2016 | NASH | 92 |
| Kanwal, 2018 [22] | USA | RCS | 2003–2011 | NAFLD | 490 |
| Kodama, 2019 [23] | Japan | RCS | 2000–2016 | NAFLD | 104 |
| Koh, 2019 [24] | Singapore | PCS | 2000–2015 | NAFLD | 152 |
| Leung, 2015 [25] | Australia | RCS | 2000–2012 | NAFLD | 54 |
| Liu, 2014 [26] | Switzerland, United Kingdom | - | - | NAFLD | 100 |
| Mohamad, 2015 [27] | USA | RCS | 2003–2012 | NAFLD | 83 |
| Pinero, 2018 [28] | Argentina | PCS | 2009–2016 | NAFLD | 81 |
| Piscaglia, 2016 [29] | Italy | PCS | 2010–2012 | NAFLD | 145 |
| Sanyal, 2010 [30] | USA | RCS | 2002–2008 | NAFLD | 2578 |
| Tateishi, 2015 [31] | Japan | RCS | 1991–2010 | NAFLD | 403 |
| Than, 2017 [32] | United Kingdom | RCS | 2000–2014 | NAFLD | 212 |
| Tobari, 2020 [33] | Japan | PCS | 1991–2018 | NAFLD | 119 |
| Tokushige, 2013 [34] | Japan | RCS | 2006–2009 | NAFLD | 292 |
| van Meer, 2016 [35] | the Netherlands | - | 2005–2012 | NAFLD | 181 |
| Wong, 2017 [36] | USA | RCS | 1991–2011 | NAFLD | 5898 |
| Yang, 2018 [37] | China | RCS | 2003–2014 | NAFLD | 96 |
| Yasui, 2019 [38] | Japan | RCS | 1993–2010 | NASH | 87 |
| Yoon, 2018 [39] | Republic of Korea | RCS | 2005–2015 | NAFLD | 63 |
a Studies including subjects with NAFLD- with or without NASH-associated HCC were classified as “NAFLD”, while studies including subjects with NASH-associated HCC only were classified as “NASH”; b in Best, 2020 [14] data from the Japanese cohort were not extracted due to overlap with Tateishi, 2015 [31]; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; PCS, prospective cohort study; RCS, retrospective cohort study; -, not reported.