Figure 5.

The co-occurrence network of differential metabolites and their maternal–fetal repercussions. The circles: differential metabolites; the diamonds: maternal FPG or fetal body weight or crown–rump length; the squares: the metabolism pathways that metabolites participated in. The blue circles represent the downregulated metabolites compared to CON, and the red circles represent upregulated metabolites. The size of circles means the VIP. Blue lines represent significantly negative associations between metabolites and maternal FPG or fetal body weight or crown–rump length, while the red lines represent significantly positive associations. Grey dotted lines represent no significant association. (a) The association of metabolites with maternal FPG during the second and third trimesters. (b) The association of metabolites with fetal body weight and crown–rump length. FPG1: fasting plasma glucose in the second trimester; FPG2: fasting plasma glucose in the third trimester.