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. 2021 Oct 16;22(20):11177. doi: 10.3390/ijms222011177

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Graphs show the effect of intrathecal capsazepine treatment on the suppression of glutamate concentration in the spinal cord (A) and serum (B) of mice with carrageenan-induced inflammatory pain. Spinal glutamate concentration was significantly higher in carrageenan-injected animals (CR, n = 5) than in the control group (Control, n = 5, * p < 0.05). Glutamate concentration in the spinal cord was significantly lower in intrathecal capsazepine-treated animals (CZP + CR, n = 5) than in the carrageenan-injected group (# p < 0.05). Serum glutamate concentration was significantly higher in carrageenan-injected mice (CR, n = 5) and capsazepine-administered mice (CZP + CR, n = 5) than in control mice (Control, * p < 0.05). No significant differences (N.S) were observed in glutamate concentration between intrathecal capsazepine-treated mice and the carrageenan-treated group.