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. 2021 Sep 29;11(10):1027. doi: 10.3390/life11101027

Figure 1.

Figure 1

Stages and anatomical locations of hematopoietic development in zebrafish. (A) In the first 24 h of development, mesoderm is specified from which all subsequent blood and endothelial cells will emerge (see gene lists for markers of different mesodermal populations). The primitive wave of hematopoiesis generates early red blood cell and immune populations. (B) Over the next two days in a definitive wave of hematopoiesis, HSCs will be produced from HE in the dorsal aorta by EHT and seed distant hematopoietic niches for expansion and lifelong blood production. EHT endothelial-to-hematopoietic transition, CHT caudal hematopoietic tissue, CVP caudal vein plexus, DA dorsal aorta, PCV posterior cardinal vein. Figure created with BioRender.com.