Table 2.
Mean ± standard deviation drug delivered across three devices with differing ventilation strategies, humidification types and drug concentrations.
| Device Type | Ventilation Type | Circuit Position |
Humidification Type | Drug Delivery (µg) Mean ± SD |
Drug Delivery (%) Mean ± SD |
|---|---|---|---|---|---|
| VMN | STD | Dry side | ACTIVE | 632.92 ± 61.95 | 25.32 ± 2.48 |
| Between HME and ETT | PASSIVE | 674.77 ± 41.19 | 26.99 ± 1.99 | ||
| LTV | Dry side | ACTIVE | 565.23 ± 66.36 | 22.61 ± 2.65 | |
| JN | STD | Inspiratory limb | ACTIVE | 288.60 ± 43.90 | 11.54 ± 1.76 |
| Between HME and ETT | PASSIVE | 247.08 ± 30.24 | 9.88 ± 1.21 | ||
| LTV | Inspiratory limb | ACTIVE | 131.08 ± 18.92 | 5.24 ± 0.76 | |
| pMDI/CombiHaler | STD | Inspiratory limb | ACTIVE | 124.62 ± 18.68 | 31.15 ± 4.67 |
| pMDI/MiniSpacer | 84.62 ± 8.97 | 21.15 ± 2.24 | |||
| pMDI/F&P Wye | At the wye | 56.92 ± 5.22 | 14.23 ± 1.30 | ||
| pMDI/MiniSpacer | Between HME and ETT | PASSIVE | 80.00 ± 4.49 | 20.00 ± 1.12 | |
| pMDI/CombiHaler | LTV | Inspiratory limb | ACTIVE | 134.46 ± 7.58 | 33.62 ± 1.90 |
| pMDI/MiniSpacer | 68.92 ± 3.67 | 17.23 ± 0.92 | |||
| pMDI/F&P Wye | 75.38 ± 8.14 | 18.85 ± 2.04 |