Figure 2.

Pathological findings from pelvic bone allograft biopsies obtained upon infection recurrence, six months after phage therapy has been discontinued. (a) Lamellar bone fragments (stars) appear necrotic, displaying only empty osteocyte lacunae; immediate surroundings are infiltrated with inflammation-inducing figurative elements of blood with numerous leucocytes (arrows). (b) Necrotic bone fragment (star) is lysed by a massive osteoclast (white arrows). Immediate surroundings are again infiltrated with numerous leucocytes (black arrows).