Table 2.
Clinical Trials in the US and Europe. A = Completed, phase 1, no results posted; B = Completed, phase 2, no results posted; C =Terminated, efficacy standard not met; D = Completed, phase 2, results posted, not publicly available; E = Unknown status, no results posted; F = Completed, no phase listed, no results posted.
| Study | Clinical Trial # and Results | Sponsor |
| ACI-24 | NCT02738450 A | AC Immune SA |
| Basmisanil/RG1662 | NCT01436955 A; NCT01667367 A; NCT02024789 B; NCT02484703 C | Hoffman/La Roche |
| Donepezil hydrochloride (Aricept) | NCT00675025 C; NCT00754013 C; NCT00754052 C; NCT00570128 | Eisai Inc./Pfizer |
| epigallocatechin-3-gallate (EGCG) | NCT01394796 D; NCT01699711 [31] | Parc de Salut Mar |
| Folic Acid | NCT01244347 E | Azienda Ospedaliera Universitaria Integrata Verona |
| Folinic Acid and L-thyroxine | NCT01576705 [74] | Institut Jerome Lejeune |
| Glulisine | NCT02432716 D | HealthPartners Institute |
| Memantine | NCT00240760 E | King’s College, London |
| Memantine | NCT01112683 [75,76] | University of Colorado, Denver |
| Memantine | NCT02304302 B | University Hospitals Cleveland Medical Center |
| Myinositol (ELDN005) | NCT01791725 [77] | OPKO Health, Inc. |
| Rivastigmine | Clinical Trial # unknown [78]; NCT01084135 [79] | Duke University |
| Rivastigmine | NCT00748007 F | National Taiwan University Hospital |
| Sleep Apnea | NCT03267602 F | National Taiwan University Hospital |
| Sleep Apnea | NCT03942341 E | Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau |
| Vitamin E | NCT00056329 [80]; NCT01594346 | New York State Institute for Basic Research |
| Upcoming/Recruiting Studies | Clinical Trial # | Sponsor |
| Gonadorelin (GnRH) | NCT04390646 | Nelly Pitteloud, Centre Hospitalier Universitaire Vaudois |
| Nicotine | NCT01778946 | Vanderbilt University Medical Center |
| Sleep Apnea | NCT04115878 | University of Arizona |
| ACI-24 | NCT04373616 | AC Immune SA |
| Sleep Apnea | NCT04132999 | Children’s Hospital of Philadelphia |
| Sleep Apnea | NCT04198493 | Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau |
| Sleep Apnea | NCT04801771 | Inspire Medical Systems, Inc. |
| Transcranial Photobiomodulation (tPBM) | NCT04668001 | Massachusetts General Hospital |
| Transcranial Photobiomodulation (tPBM) | NCT04211870 | University of Nove de Julho |