Table 1.
Sociodemographic and clinical characteristics of the study population.
| Responders (n = 880) |
Non Responders (n = 70) |
Controls (n = 50) |
p Value Comparison 3 Groups |
p Value Comparison Responders vs. Non Responders |
|
|---|---|---|---|---|---|
| Age | 47.83 ± 9.78 (30–70) |
50.14 ± 9.5 (32–71) |
49.62 ± 9.024 (33–69) |
0.082 | 0.0549 |
| Sex M/F | 418/462 (47.5/52.5) | 33/37 (47.1/52.9) | 30/20 (60/40) | 0.224 | 0.99 |
| Smoking | 286 (32.5) | 20 (28.6) | 0 | <0.001 | 0.51 |
| Comorbidities | 528 (60) | 57 (81.4) | 0 | <0.001 | <0.001 |
| Severity of liver disease Non-cirrhotic Cirrhotic |
748 (85) 132 (15) |
26 (37.1) 44 (62.9) |
0 0 |
<0.001 | <0.001 |
| HCC incidence | 0 | 25 (35.7) | 0 | <0.001 | <0.001 |
| IL-13 (pg/mL) | 102 ± 20.6 (24–187) |
308.9 ± 113.4 (136–542) |
75.2 ± 4.8 (58–81) |
<0.001 | <0.001 |
| miRNA-135a (fold change) | 2.1 ± 0.9 (0.4–4.6) |
4.6 ± 0.7 (2.7–6.7) |
1.2 ± 0.25 (0.7–1.6) |
<0.001 | <0.001 |
| VIT D (ng/mL) | 32.2 (2.5–71) | 12.65 (2–45) | 44.1 (30–70) | <0.001 | <0.001 |
| HCV-RNA (IU/mL) | 4.7 × 105 (0.8 × 103–6 × 108) |
9.6 × 106 (1.2 × 104–1.26 × 108) |
- | - | <0.001 |
Values are presented as mean ± standard deviation (range), median (minimum-maximum) or n (%) unless otherwise indicated. p-value < 0.05 means significant. For comparison between the groups one-way ANOVA analysis or Kruskal–Wallis and Mann–Whitney or Student’s t-test is used to compare between the two groups. HCC: hepatocellular carcinoma. IL-13: Interleukin 13. Vit D: Vitamin D. Comorbidities: Hypertension, DM.