The 3D structures (surface and ribbon views) of human CDs and the Spike-RBD interactions. For interacting residues, see Table 2 and the corresponding supplement 2D Figure(s). (A) The Spike-RBD (fire brick) binding to human CD15 (light green) (corresponding to complex 3, Figure S9, 13 H-bonds, involving four regions of the Spike-RBD; (B) The Spike-RBD (fire brick) binding to human CD27 (sky blue) (corresponding to complex 9, Figure S13, 10 H-bonds, involving four regions of the Spike-RBD, (C) The Spike-RBD (fire brick) binding to human CD45 (gold) and the Spike-RBD (corresponding to complex 8, Figure S19, eight H-bonds, involving four regions of the Spike-RBD, and (D) The Spike-RBD (fire brick) binding to human CD152 (slate grey) and the Spike-RBD (corresponding to complex 2, Figure S26, 11 H-bonds, involving four regions of the Spike-RBD).