Table 3.
Interacting human microtubule ring complex protein residues (bold) with SARS-CoV-2 protein residues (Roman).
| Protein Complexes | Docked Complex Number | Interacting Residues |
|---|---|---|
|
GCP2-CoV-2 M Protein (Lateral Position) |
7 | Arg290-Cys33, Arg290-Thr30, Trp353-Thr30, Trp353-Phe26, Gln350-Lys50, Ser283-Asn43 |
| 3 | Ser243-Ser173, Ser243-Arg174, Thr235-Arg198, Arg290-Leu56, Ser393-Asn5, Ser393-Thr7 | |
|
GCP2- Orf3a (Lateral Position) |
4 | Arg361-Asp210, Ser393-Ile236, Glu242-Lys61, Asp397-Ser209, Trp353-Asp142, Arg290-Tyr189 |
|
GCP3-Orf3a (Lateral Position) |
7 | Arg333-Asp142, Arg252-Ser165, Ser323-Lys61, Gln322-Lys61, His343-Asp210 |
| 3 | Tyr256-Val163, Arg252-Val163, Arg337-Ile118, Arg333-Asn119, Gln416-Tyr107, Arg315-Lys61, Gln322-Ser58 | |
|
GCP2-M Protein (At GCP2 residues that interact with TUBG1) |
5 | Asp554-Lys205, Tyr723-Asn117, Arg711-Glu137, Asp561-Thr208, Ser885-Arg101 |
| 1 | Ser885-Arg105, Ser885-Arg101, Cys684-Cys86, Glu731-Gln36 | |
|
GCP3-M Protein (At GCP3 residues that interact with TUBG1) |
1 | Phe612-Gln36, Gln570-Gln36, Ser709-Arg131, Ser709-His154, Lys689-Glu137, Thr678-Arg107, Glu728-Arg42, Gly569-Arg42, Tyr720-Asn41, Lys671-Tyr39 |
| 5 | Phe612-Gln36, Arg681-Glu137, Glu728-Arg42, Ser709-His154, His716-Arg107, Asn883-His155, Gly571-Arg105, Asp572-Arg105 | |
|
GCP2-Orf3a (At GCP2 residues that interact with TUBG1) |
3 | Cys684-Val163, Gln719-Ser166, Tyr723-Ser166, Asn890-Tyr215 |
| 9 | Gln722-Lys192, Gln719-Trp193, Cys684-His182, Asn716-Cys153, Gln712-Asn152, Asp561-His227, Arg681-Gly174 | |
|
GCP3-Orf3a (At GCP3 residues that interact with TUBG1 |
1 | His716-Asp210, Tyr720-Asp210, Asn883-Asn144, Gln717-Tyr145, Ser709-Ser162, Arg681-Ser166, Arg681-Thr164, Thr678-Ser165 |
| 3 | His702-Leu83, Glu728-Lys192, Asn609-Thr151, Gln570-Asn152, Gln717-Trp69 | |
|
TUBG1-M Protein (At TUBG1 residues that interact with GCP2) |
1 | Pro350-Arg131, Trp351-Arg131, Asp442-His125, Arg341-Leu134, Asn251-Gln36, His334-Arg101, Tyr248-Tyr47, Asp252-Arg42 |
| 7 | Leu276-Arg44, Tyr273-Arg42, Lys363-Phe37, Glu38-Arg105, Ser32-Arg101, Lys23-Arg105, Ser80-107, Thr234-Tyr39, Thr234-Asn41 | |
| 8 | Glu426-Arg131, Pro162-Arg42, Asp200-Arg42, Gln197-Trp110, Pro-264-Tyr39, Thr196-Asn41, Arg265-Asn41, Asp433-Arg107, Asp419-Thr127, Asp422-His125 | |
|
TUBG1-M Protein (At TUBG1 residues that interact with GCP3) |
1 | Pro350-Arg131, Trp351- Arg131, Asp442-His125, Arg341-Leu134, Asn251-Gln36, His334-Arg101, Tyr248-Tyr47, Asp252-Arg42 |
| 8 | Glu426-Arg131, Pro162-Arg42, Asp200-Arg42, Gln197-Trp110, Pro-264-Tyr39, Thr196-Asn41, Arg265-Asn41, Asp433-Arg107, Asp419-Thr127, Asp422-His125 | |
| 9 | Gln357-Thr127, Thr331-Arg131, His334-Leu156, Ser355-His125, Arg341-Asp160, Glu327-Asn41 | |
|
TUBG1-orf3a (At TUBG1 residues that interact with GCP2) |
3 | Val130-Lys136, Arg212-Tyr154, Arg390-Arg134, Arg390-Asp134, Asp216-Arg68, Arg343-Leu83, Gln394-Asn152 |
| 1 | Arg341-Phe207, His334-Tyr211, Gln357-Ile124, Tyr248-Cys130 | |
|
TUBG1-orf3a (At TUBG1 residues that interact with GCP3) |
1 | Arg341-Phe207, His334-Tyr211, Gln357-Ile124, Tyr248-130 |
| 3 | Val305-Lys136, Arg212-Tyr154, Arg390-Asp155, Arg390-Arg134, Asp216-Arg68, Arg343-Leu83, Gln394-Asn152 |