Table 4.
Interacting Epstein–Barr virus LMP-1 and human PD residues with SARS-CoV-2 protein residues. The non-SARS-CoV-2 protein residues are shown in bold.
| Protein Complexes | Docked Complex Number | Interacting Residues |
|---|---|---|
| LMP-1 and 3CLpro/Mpro | 1 | His352-Asn274, Tyr384-Asn274, Tyr385-Gly275, Leu382-Asn277, Ser383-Asn277, Ser367-Ala285 |
| 9 | Ser383-Asn277, Tyr385-Arg279, Tyr384-Glu270, Ser313-Glu270, Ser313-Lys269, Thr324-Gln273, Glu328-Lys236 | |
| 10 | Gln381-Arg298, Gln381-Gly302, Gln381-Ser301, Gly345-Thr304, Asp341-Gln306, Asp341-Phe305, Ser347-Ser1, Ser383-Ser1, Val228-Arg4, Ala231-Phe3 | |
| LMP-1 and NSP7 | 6 | Ser383-Leu60, Tyr385-Leu59, Tyr385-Met62, Ser367-Met62, Ser367-Leu20, Gly368-Leu20, Gly371-Arg21, Ser369-Ser24 |
| 7 | Tyr384-Gly64, Ser313-Lys70, Tyr385-Leu59, Tyr385-Met62, Gln381-Ser61, Ser367-Ser61, Ser367-Val58, Gly371-Ser26 | |
| 8 | Ser313-Lys70, Ser367-Leu20, Tyr385-Met62, Tyr385-Leu59, Tyr385-Val66, Ser383-Leu60, Gln381-Ser61 | |
| LMP-1 and NSP10 | 2 | Ser313-Asp65, Ser383-His63, Gln381-His63, Tyr384-His63, Tyr385-His63, Ser367-Arg61, Gly365-Cys62, Glu325-Asp5 |
| 8 | Tyr385-Ser112, Tyr385-Arg117, Ser383-Arg117, Tyr384-Cys113, Gln381-Glu118, Ser347-Leu121, His346-Gln122, Thr324-Val102 | |
| LMP-1 and Spike RBD | 6 | His352-Tyr489, Gln381-Gln493, Tyr384-Tyr489, Tyr384-Asn487, Tyr385-Lys417 |
| 7 | Tyr384-Asn487, His352-Asn487, His352-Tyr489, Asp386-Tyr421, Ser367-Leu492, Ser367-Phe490, Ser367-Gln493 | |
| 8 |
Pro376-Asn501, Pro376-Gln498, Gly344-Tyr453, Asp341-Lys417, Tyr385-Phe486, Ser229-Asn487, Gln381-Glu484 |
|
| PD-1 and Spike RBD | 2 | Thr53-Tyr505, His107-Tyr505, Arg104-Tyr505, Ser55-Tyr453, Thr36-Tyr453, Glu136-Tyr489, Lys135-Cys488, Trp32-Glu484, Asn58-Tyr449 |
| 7 | Ser127-Tyr489, Ala129-Tyr489, Leu100-Tyr449, Pro101-Gln498, Phe63-Gln493, Tyr68-Glu484 | |
| 8 | Asp77-Gln493, Lys78-Phe490, Arg94-Tyr505, Ile126-Phe486, Gln75-Tyr449, Ser71-Tyr449, Ser71-Gly446, Ser73-Gly446 |