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. 2021 Oct 19;22(20):11293. doi: 10.3390/ijms222011293

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pro-angiogenic secreted factors are released by coELTD1 expressing cells, including IL1. (A) ProteomeProfiler^TM Angiogenesis Array (R&D Systems) using supernatant collected from control and coELTD1 HUVEC collected at 120 h. (B) Quantification of the Angiogenesis array and comparison with RNA expression level. (C) Quantification of IL1 and IL8 secretion at 120 h using ELISA. (D) Expression of IL1 target genes upon IL1 treatment +/− IL1-receptor antagonist. * p < 0.05; ** p < 0.005; *** p < 0.0005.