TABLE 2.

Antigenic domains and regions within the HEV ORF2-encoded protein as modeled with synthetic peptides immunoreactive with IgM anti-HEV antibodies

Domain	Domain positions (aa)	No. of epitopes within domain	25-mer peptides			30-mer peptides
			No. of Aga regions	Positions (aa)	No. of reactive peptides	No. of Ag regions	Positions (aa)	No. of reactive peptides
1	12–147	5	2	12–68	5	2	12–41	1
				57–138	10		24–147	11
2	143–222	3	3	126–158	2	2	124–187	3
				167–201	2		188–217	1
				198–232	2
3	221–373	5	5	222–246	1	2	221–274	5
				251–275	1		271–355	8
				270–294	1
				301–333	2
				328–352	1
4	381–504	5	1	403–465	7	2	381–471	10
							457–520	5
5	490–579	4	4	490–514	1	1	538–580	3
				511–535	1
				539–563	1
				552–576	1
6	573–660	2	1	601–660	6	1	592–660	7

^aAg, antigenic.