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. 2021 Oct 22;14:140. doi: 10.1186/s13048-021-00886-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Confirmation of PARP1i-induced protein networks in HGSOC cell lines. Protein network and pathway analysis were performed on independent L1000 transcriptome dataset for HGSOC cell lines RMUGS, COV644 and TYKNU treated with pan-PARPi olaparib and rucaparib as described previously (FDR-corrected p-value < 0.05; Material and Methods, STable3). (a, b) Barplots represents top 5 frequently responding annotated protein modules (adj. p-value < 0.05) across all cell lines (STable3). (c) Correlation analysis of the overall protein module activity based on overlapping annotated modules between L1000 olaparib-treated RMUGS cell line and proteome profiling. Activity was calculated by integrating protein expression changes in modules [38] (Methods)