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HPV-11-positive cells detected by DNA-ISH and RNA-ISH in LP. HPV-11 DNA was strongly observed from the middle to upper third cell layers in this representative case. A signal for E6 mRNA was not observed. E2 mRNA was weakly expressed from the middle to upper third layers. E4 and E5b mRNAs were strongly expressed in the upper third cell layer in LP. Bar = 100 μm.
