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. 2021 Oct 14;22(20):11085. doi: 10.3390/ijms222011085

Figure 2.

Figure 2

KDM7A overexpression increases DGAT2 expression and intracellular TG levels in AML12 cells. AML12 cells were infected with Ad-GFP or Ad-KDM7A. (A) Protein levels of KDM7A, H3K9me, H3K27me2 and DGAT2 were measured by Western blotting. (B) mRNA levels of KDM7A and DGAT2 were measured by qPCR. (C) Intracellular TG levels were measured using a TG assay kit. Data are presented as the mean ± SD from three independent experiments. ** p < 0.01, *** p < 0.001 vs. control (Ad-GFP). (D) AML12 cells were infected with Ad-GFP or Ad-KDM7A and then treated with PF-06427878 for an additional 24 h. Intracellular TG levels were measured using a TG assay kit. Data are presented as the mean ± SD from three independent experiments. ** p < 0.01 vs. control (Ad-GFP), ## p < 0.01 vs. Ad-KDM7A without PF-06427878 treatment.