Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The putative intracellular activation pathway of TAF. TAF exhibits a significantly improved cell permeability compared to tenofovir. After cell entry, TAF is hydrolyzed by CatA and CES1 and is converted to its alanine metabolite (TFV-Ala) following several rapid chemical reaction steps. TFV-Ala is further hydrolyzed by HINT1 to form the monophosphonate product, tenofovir, which is subsequently phosphorylated by kinases to generate the active metabolite tenofivir-diphosphote (TFV-DP).
