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. 2021 Oct 11;13(10):1656. doi: 10.3390/pharmaceutics13101656

Figure 4.

Figure 4

Activity of rhCatA (a) and rhCES1 (b) for TAF and SBV hydrolysis. 0.5 ng/µL rhCatA and 40 ng/µL rhCES1 were incubated with 20 µM TAF or SBV at 37 °C for 5 and 20 min, respectively. The enzyme activity was calculated by dividing the disappearance amount of the prodrug by the enzyme concentration and incubation time. Bars show mean values (±S.D.) of three independent experiments (n = 3). * p < 0.05 and ** p < 0.01 indicate statistically significant difference between TAF and SBV groups by Student’s t-test.