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Time course of CMR-PVA200-PLGA-NS released from PH. (A) Time-lapse fluorescent microscopic images 0, 3, 6, 12, 24, and 48 h after incubation of PH. Scale bar is 10 µm. (B) Time profile of CMR release from PH. (C) Enlarged fluorescent microscopic images of red frame boxes indicated in (A). The values of Texp indicates exposure time in the corresponding incubation periods. Scale bar is 5 µm. (D) The scheme of plausible mechanism on the release of CMR-PVA200-PLGA-NS from PH.
