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. 2021 Oct 15;11(10):1032. doi: 10.3390/jpm11101032

Table 1.

Influence of gene polymorphisms on glatiramer acetate therapy in Caucasian patients with multiple sclerosis.

Gene Year N Ethnicity Polymorphism Overall Response Rate PMID
p-Value OR (95% CI) Genotype
Associated
ALOX5AP 2017 639 Multinational * rs10162089 0.008 1.56 T 28569182
532 Multinational * rs10162089 0.032 1.58 T
CD86 2007 35 Belgium, Canada, The Netherlands, Italy, and the UK rs1129055 0.022 6.28 (1.3–30.3) C 17622942
48 Belgium, Canada, The Netherlands, Italy, and the UK rs2001791 0.062 8.3 (0.9–77.0) T
CLEC16A 2017 296 Russian rs6498169 0.025 2.38 (1.08–5.27) A 29095108
CTSS 2007 43 Belgium, Canada, The Netherlands, Italy, and the UK rs2275235 0.014 11.59 (1.6–81.9) G 17622942
47 Belgium, Canada, The Netherlands, Italy, and the UK rs1415148 0.009 6.85 (1.6–29.2) A
EOMES 2017 296 Russian rs2371108 0.018 2.00 (1.09–3.66) T 29095108
FAS 2007 47 Belgium, Canada, The Netherlands, Italy, and the UK rs982764 0.050 2.97 (1.0–8.8) C 17622942
IL1RL1 2007 48 Belgium, Canada, The Netherlands, Italy, and the UK rs956730 0.025 5.81 (1.2–27.1) A 17622942
IL12RB2 2007 34 United States of America rs946685 0.027 0.24 (0.07–0.85) G 17622942
IL22RA2 2017 296 Russian rs202573 0.008 2.08 (1.18–7.41) GG 29095108
HLA-DRB1 2011 332 United States of America rs3135388 0.015 2.7 (1.2–6.0) AA 21115201
MAGI2 2017 639 Multinational * rs16886004 0.002 2.15 A 28569182
532 Multinational * rs16886004 <0.001 5.56 A
MBP 2007 32 Belgium, Canada, The Netherlands, Italy, and the UK rs470929 0.040 5.3(1.1–25.9) T 17622942
2017 639 Multinational * rs1789084 0.036 0.7 T 28569182
PTPRT 2017 639 Multinational * rs1117602254 0.004 0.21 C 28569182
532 Multinational * rs1117602254 0.016 0.28 C
PVT1 2017 296 Russian rs2114358 0.005 2.77 (1.33–5.77) A 29095108
RFPL3 2017 532 Multinational * rs1789084 0.010 0.57 C 28569182
532 Multinational * rs73166319 <0.001 0.12 C
SLC1A4 2017 639 Multinational * rs759458 <0.001 3.31 G 28569182
532 Multinational * rs759458 0.049 1.86 G
TRBC 2007 31 Belgium, Canada, The Netherlands, Italy, and the UK rs71878 0.015 6.8 (1.45–31.9) C 17622942
UVRAG 2017 639 Multinational * rs80191572 0.002 0.20 A 28569182
532 Multinational * rs80191572 <0.001 0.12 A
ZAK 2017 639 Multinational * rs139890339 <0.001 0.05 C 28569182
532 Multinational * rs139890339 0.011 0.14 C

* Argentina, Belgium, Bulgaria, Canada, Croatia, the Czech Republic, Estonia, Finland, France, Georgia, Germany, Hungary, Israel, Italy, Latvia, Lithuania, The Netherlands, Poland, Romania, Russia, South Africa, Spain, Ukraine, the UK, and the United States.