Fig. 11.

Oxygenation (PaO₂) and dynamic lung compliance in surfactant-deficient rabbits treated with aged B-YL surfactant (n = 6) compared to porcine surfactant (Curosurf®, n = 4) and lipids only surfactant (n = 4). Surfactant treatment was given intratracheally at time 0 min, after surfactant deficiency was induced by repeated lung lavages with warmed normal saline. Oxygenation (arterial PO₂ in left-sided graph) quickly increased to levels close to the baseline values and reached similar terminal values after treatment with B-YL and Curosurf®, but did not change significantly after treatment with lipids only. Dynamic compliance followed a similar pattern, but the increase in compliance occurred slower and terminal values for B-YL and Curosurf® were equal but below the baseline levels. Baseline (2017) in vivo data can be found in reference 7