Table 1.

Cytotoxicity of the synthesized compounds in cancer (22Rv1) versus non-cancer (PNT2) prostate cells. Selectivity index values (ratio of IC₅₀ in PNT2 cells to IC₅₀ in 22Rv1 cells). “#” indicates that IC₅₀ values toward the tested cell lines were >100 μM. The values of IC₅₀ correspond to those presented in Table 2. All IC₅₀ values were evaluated after 48 h of treatment using the MTT test.

Compound	IC50(22Rv1), [μM]	IC50(PNT2), [μM]	Selectivity Index [IC50(PNT2)/IC50(22Rv1)]
11	>100	>100	n/a
12	89.5 ± 24.9	>100	n/a
26	41.2 ± 1.18	>100	n/a
27	>100	>100	n/a
28	93.35 ± 28.6	>100	n/a
29	32.06 ± 1.66	6.44 ± 1.24	0.2
30	0.36 ± 0.09	0.49 ± 0.09	1.36
31	0.51 ± 0.18	0.38 ± 0.03	0.75
32	0.14 ± 0.09	0.77 ± 0.07	5.5
33	0.75 ± 0.16	0.85 ± 0.04	1.13
34	>100	>100	n/a
35	>100	>100	n/a
36	>100	>100	n/a
37	48.55 ± 12.2	28.15 ± 1.04	0.58
38	>100	>100	n/a