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Scheme and scanning electron microscopy images of different steps of primary hemostasis. The resting platelets in the bloodstream (step 1) adhere to the endothelial or sub-endothelial matrix at site of the vascular lesion (step 2). Intra-platelet signal transduction induces platelet activation (step 3) followed by platelet aggregation (step 4) and platelet plug formation (step 5).
