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. 2021 Oct 11;22(20):10973. doi: 10.3390/ijms222010973

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Unique features of colon submucosal fibroblasts. (A) Gene set enrichment analysis (GSEA) was performed using the microarray datasets of colon normal fibroblasts (NFs) and cancer-associated fibroblasts (CAFs). Expression profiling data of colon NFs and colorectal CAFs were obtained from the GSE70468 dataset. A colon SMF-specific signature was identified by differential expression analysis between the colon SMFs (4 samples) and non-GIFs (31samples) obtained from the GSE63626 dataset. SMFs: submucosal fibroblasts. GIFs: gastrointestinal fibroblasts. (B) Heatmap of the relative expression levels of 30 leading-edge genes obtained by GSEA.

Unique features of colon submucosal fibroblasts. (A) Gene set enrichment analysis (GSEA) was performed using the microarray datasets of colon normal fibroblasts (NFs) and cancer-associated fibroblasts (CAFs). Expression profiling data of colon NFs and colorectal CAFs were obtained from the GSE70468 dataset. A colon SMF-specific signature was identified by differential expression analysis between the colon SMFs (4 samples) and non-GIFs (31samples) obtained from the GSE63626 dataset. SMFs: submucosal fibroblasts. GIFs: gastrointestinal fibroblasts. (B) Heatmap of the relative expression levels of 30 leading-edge genes obtained by GSEA.