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. 2021 Oct 11;22(20):10973. doi: 10.3390/ijms222010973

Figure 2.

Figure 2

Upregulated genes in CAFs identified in different cancer types. (A) Venn diagram showing the genes upregulated in CAFs relative to NFs in colorectal cancer (CRC), gastric cancer and non-small cell lung cancer. The number of identified genes is indicated. Representative overlapping genes are indicated. Upregulated genes in CAFs were identified as follows. CRC: expression profiling data by microarray were obtained from the GSE70468 dataset. Upregulated genes in CAFs relative to their normal counterparts were extracted by the thresholds of a p-value < 0.05 and log fold-change > 1. Gastric cancer: fragments per kilobase of exon per million reads mapped (FPKM) data of 11 matched NFs and CAFs were obtained from the GSE83834 dataset. Deseq2 was performed and the top 300 upregulated genes were extracted. Non-small cell lung cancer: expression profiling data by microarray were obtained from the GSE22874 dataset. Upregulated genes in CAFs relative to NFs were extracted by the thresholds of a p-value < 0.05 and log fold-change > 1. (B) Pathway analyses (KEGG and Wiki pathways) were performed using CAF-upregulated genes in at least two cancer types.