Changes in the prevalence of IGRA-positive results across age groups. The prevalence of LTBI was based on a positive T-SPOT.TB or QuantiFERON assay (QFT-GIT or QFT-Plus). The prevalence of LTBI increased with age among the CoC (P=<0.001) but not for ReC (P=0.354). LTBI was significantly higher among CoC vs ReC until aged 59 (non-overlapping 95% CIs) but not among those aged ≥60 years. The proportion of newly-infected individuals in the ReC groups was calculated by subtracting LTBI-positives from the baseline CoC group (line with triangles).
CoC, Community controls; ReC, Recent contacts; LTBI, latent M. tuberculosis infection. Vertical bars, 95% CIs for LTBI prevalence. IGRA, Interferon-gamma release assay; QFT, QuantiFERON-Gold In-Tube and -Plus