Multipurpose solutions (MPSs) and contact lenses challenged with Fusarium keratoplasticum ATCC 36031 at (A) the manufacturer’s disinfection time (DT), (B) 24 h, and (C) 7 days. Disinfection efficacy is stated in mean ± standard error log reduction compared to inoculum control. The dashed line represents ISO 14729 antimicrobial efficacy testing. * p < 0.05 vs. no-lens challenge at the same time point and within the same MPS. Statistical differences among product families: a p < 0.05 vs. OPTI-FREE (OF) Puremoist with Air Optix HG, b p < 0.05 vs. OPTI-FREE Express with Air Optix HG, c p < 0.05 vs. OPTI-FREE Replenish with Air Optix HG, d p < 0.05 vs. RevitaLens with Vita, e p < 0.05 vs. renu Advanced with Ultra, f p < 0.05 vs. renu MultiPlus with Ultra, g p < 0.05 vs. Lite with Vitality, h p < 0.05 vs. Biotrue with Ultra; aa p < 0.05 vs. OPTI-FREE Puremoist with other manufacturer lens, bb p < 0.05 vs. OPTI-FREE Express with other manufacturer lens, cc p < 0.05 vs. OPTI-FREE Replenish with other manufacturer lens. n = 3/group.