Table 1.
Characterization of DXR-responsive and non-responsive NP. Values reported as mean ± standard deviation of n = 5 independent NP preparations.
| DXR-NP (n = 5) |
Size, nm (PDI) |
Zeta Potential (mV) | % Loading Efficiency | Drug-to-Lipid Ratio (w/w) | % of Cell Associated DXR (6 h Incubation) with MDA-MB-231 Cells | Release Kinetics Fitting Parameters y = y∞ + exp(−t/τ 1/2 ) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| pH 7.4 | pH 6.5 | ||||||||||
| pH 7.4 | pH 6.0 | pH 7.4 | pH 6.5 | y ∞ (%) | τ1/2 (min) | y ∞ (%) | τ1/2 (min) | ||||
| Responsive | 162 ± 19 (0.11 ± 0.06) |
−5.91 ± 0.60 | −5.74 ± 0.89 | 61 ± 4 | 0.066 ± 0.011 | 1.09 ± 0.18 | 1.71 ± 0.24 | 90 ± 1.2 | 66 ± 31 | 70 ± 1.3 | 21 ± 4.2 |
| Non-Responsive | 123 ± 6 (0.09 ± 0.05) |
−4.57 ± 0.63 | −4.15 ± 0.52 | 71 ± 8 | 0.090 ± 0.016 | 0.79 ± 0.16 | 0.84 ± 0.31 | 90 ± 1.3 | 120 ± 56 | 90 ± 0.9 | 54 ± 18 |